ProteinToMusic — Protein to Jazz Music

Input Parameters

Protein Name

Species *

Codon usage bias affects chord frequency mapping; choose the species closest to the protein's origin

Sequence

Chain 1

PDB Structure File

Upload a PDB file to use its 3D structure for spatial neighbor analysis. Max file size: 200 MB. PDB-only mode: if no sequence is entered, the protein sequence is auto-extracted from the PDB. If no PDB is uploaded, ESMFold predicts the structure automatically.

Tonality

Melody Strategy

Physical Weight

0 = JazzGPT-guided ↔ 4 = Pure physics (best roundtrip)

Neighbor Cutoff (Å)

Fill in parameters on the left
and click Generate Music to start

The system maps each amino acid's physicochemical properties
onto jazz chords based on the protein's spatial structure

How It Works

Input Sequence

Enter the protein's DNA/RNA coding sequence or single-letter amino acid codes. RNA is auto-detected (U→T) and translated by triplet codon. Codon frequency determines the rhythmic weight (1–4 beats) per residue.

Upload PDB

Upload an optional .pdb structure file. The system extracts Cα coordinates and computes spatial neighbors within the cutoff distance (default 6 Å); neighbor relationships shape melody timbre selection.

Select Model

Model B (JazzGPT) uses a Transformer with jazz-theory scoring to generate smoother harmonic progressions. Physical Weight controls the blend: 0 = full JazzGPT, 4 = pure physics (identical to Model A).

Download / Play

The generated music can be played directly in the browser or downloaded as MIDI/MP3. If ESMFold was invoked, the predicted PDB structure is also available for download.